Coupling of sterically demanding peptides by β-thiolactone-mediated native chemical ligation

The ligation of sterically demanding peptidyl sites such as those involving Val–Val and Val–Pro linkages has proven to be extremely challenging with conventional NCL methods that rely on exogenous thiol additives. Herein, we report an efficient β-thiolactone-mediated additive-free NCL protocol that...

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Detalles Bibliográficos
Autores principales: Chen, Huan, Xiao, Yunxian, Yuan, Ning, Weng, Jiaping, Gao, Pengcheng, Breindel, Leonard, Shekhtman, Alexander, Zhang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892351/
https://www.ncbi.nlm.nih.gov/pubmed/29675245
http://dx.doi.org/10.1039/c7sc04744d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892351/
https://www.ncbi.nlm.nih.gov/pubmed/29675245
http://dx.doi.org/10.1039/c7sc04744d

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