Ultrasensitive and specific fluorescence detection of a cancer biomarker via nanomolar binding to a guanidinium-modified calixarene

We designed a water-soluble guanidinium-modified calix[5]arene to target lysophosphatidic acid (LPA), an ideal biomarker for early diagnosis of ovarian and other gynecologic cancers, achieving binding on the nanomolar level. An indicator displacement assay, coupled with differential sensing, enabled...

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Detalles Bibliográficos
Autores principales: Zheng, Zhe, Geng, Wen-Chao, Gao, Jie, Wang, Yu-Ying, Sun, Hongwei, Guo, Dong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892409/
https://www.ncbi.nlm.nih.gov/pubmed/29675249
http://dx.doi.org/10.1039/c7sc04989g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892409/
https://www.ncbi.nlm.nih.gov/pubmed/29675249
http://dx.doi.org/10.1039/c7sc04989g

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