Substrate clustering potently regulates the activity of WW-HECT domain–containing ubiquitin ligases

The Nedd4 family of HECT domain–containing E3 ligases ubiquitinate many transcription factors and signaling proteins, and their activity is tightly regulated. Normally, intramolecular interactions curb the catalytic activity of the HECT domain, but these can be broken by the binding of PY motifs, fo...

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Detalles Bibliográficos
Autores principales: Mund, Thomas, Pelham, Hugh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892558/
https://www.ncbi.nlm.nih.gov/pubmed/29463679
http://dx.doi.org/10.1074/jbc.RA117.000934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892558/
https://www.ncbi.nlm.nih.gov/pubmed/29463679
http://dx.doi.org/10.1074/jbc.RA117.000934

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