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Substrate clustering potently regulates the activity of WW-HECT domain–containing ubiquitin ligases
The Nedd4 family of HECT domain–containing E3 ligases ubiquitinate many transcription factors and signaling proteins, and their activity is tightly regulated. Normally, intramolecular interactions curb the catalytic activity of the HECT domain, but these can be broken by the binding of PY motifs, fo...
Autores principales: | Mund, Thomas, Pelham, Hugh R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892558/ https://www.ncbi.nlm.nih.gov/pubmed/29463679 http://dx.doi.org/10.1074/jbc.RA117.000934 |
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