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Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice
The use of rapamycin to extend lifespan and delay age-related disease in mice is well-established despite its potential to impair glucose metabolism which is driven partially due to increased hepatic gluconeogenesis. We tested whether a combination therapeutic approach using rapamycin and metformin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892694/ https://www.ncbi.nlm.nih.gov/pubmed/29579736 http://dx.doi.org/10.18632/aging.101401 |