Structures of the Mycobacterium tuberculosis GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition

The crystal structures of native class II fructose-1,6-bisphosphatase (FBPaseII) from Mycobacterium tuberculosis at 2.6 Å resolution and two active-site protein variants are presented. The variants were complexed with the reaction product fructose 6-phosphate (F6P). The Thr84Ala mutant is inactive,...

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Detalles Bibliográficos
Autores principales: Wolf, Nina M., Gutka, Hiten J., Movahedzadeh, Farahnaz, Abad-Zapatero, Celerino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892879/
https://www.ncbi.nlm.nih.gov/pubmed/29652259
http://dx.doi.org/10.1107/S2059798318002838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892879/
https://www.ncbi.nlm.nih.gov/pubmed/29652259
http://dx.doi.org/10.1107/S2059798318002838

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