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Predicting essential proteins by integrating orthology, gene expressions, and PPI networks

Identifying essential proteins is very important for understanding the minimal requirements of cellular life and finding human disease genes as well as potential drug targets. Experimental methods for identifying essential proteins are often costly, time-consuming, and laborious. Many computational...

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Detalles Bibliográficos
Autores principales: Zhang, Xue, Xiao, Wangxin, Hu, Xihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892885/
https://www.ncbi.nlm.nih.gov/pubmed/29634727
http://dx.doi.org/10.1371/journal.pone.0195410