Pharmacokinetics and interspecies scaling of a novel, orally-bioavailable anti-cancer drug, SHetA2

SHetA2 is a small molecule drug with promising cancer prevention and therapeutic activity and a high preclinical safety profile. The study objectives were to perform interspecies scaling and pharmacokinetic (PK) modeling of SHetA2 for human PK prediction. The PK data obtained from mice, rats, and do...

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Detalles Bibliográficos
Autores principales: Sharma, Ankur, Benbrook, Doris Mangiaracina, Woo, Sukyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892888/
https://www.ncbi.nlm.nih.gov/pubmed/29634717
http://dx.doi.org/10.1371/journal.pone.0194046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892888/
https://www.ncbi.nlm.nih.gov/pubmed/29634717
http://dx.doi.org/10.1371/journal.pone.0194046

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