Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cance...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Cong-Hui, Liu, Gao-Yuan, Wang, Rencheng, Moon, Sung Ho, Gross, Richard W., Patti, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892939/
https://www.ncbi.nlm.nih.gov/pubmed/29596410
http://dx.doi.org/10.1371/journal.pbio.2003782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892939/
https://www.ncbi.nlm.nih.gov/pubmed/29596410
http://dx.doi.org/10.1371/journal.pbio.2003782

Ejemplares similares