Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity

Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of a population. Heat shock factor 1 (Hsf1) regulates chapero...

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Detalles Bibliográficos
Autores principales: Zheng, Xu, Beyzavi, Ali, Krakowiak, Joanna, Patel, Nikit, Khalil, Ahmad S., Pincus, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893160/
https://www.ncbi.nlm.nih.gov/pubmed/29562166
http://dx.doi.org/10.1016/j.celrep.2018.02.083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893160/
https://www.ncbi.nlm.nih.gov/pubmed/29562166
http://dx.doi.org/10.1016/j.celrep.2018.02.083

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