Distinct moieties underlie biphasic H(+) gating of connexin43 channels, producing a pH optimum for intercellular communication

Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pH(i)), which is modulated by...

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Detalles Bibliográficos
Autores principales: Garciarena, Carolina D., Malik, Akif, Swietach, Pawel, Moreno, Alonso P., Vaughan-Jones, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893178/
https://www.ncbi.nlm.nih.gov/pubmed/29183963
http://dx.doi.org/10.1096/fj.201700876R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893178/
https://www.ncbi.nlm.nih.gov/pubmed/29183963
http://dx.doi.org/10.1096/fj.201700876R

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