Cargando…

Distinct moieties underlie biphasic H(+) gating of connexin43 channels, producing a pH optimum for intercellular communication

Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pH(i)), which is modulated by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garciarena, Carolina D., Malik, Akif, Swietach, Pawel, Moreno, Alonso P., Vaughan-Jones, Richard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893178/ https://www.ncbi.nlm.nih.gov/pubmed/29183963 http://dx.doi.org/10.1096/fj.201700876R

Ejemplares similares

Dual Role of CO(2)/HCO(3)(−) Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths
por: Hulikova, Alzbeta, et al.
Publicado: (2011)

Connexin43 Hemichannel-Mediated Regulation of Connexin43
por: Li, Kai, et al.
Publicado: (2013)

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1
por: Richards, Mark A, et al.
Publicado: (2019)

Na(+) ions as spatial intracellular messengers for co-ordinating Ca(2+) signals during pH heterogeneity in cardiomyocytes
por: Swietach, Pawel, et al.
Publicado: (2015)

Rapid and Direct Effects of pH on Connexins Revealed by the Connexin46 Hemichannel Preparation
por: Brady Trexler, E., et al.
Publicado: (1999)

Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin
por: Swietach, Pawel, et al.
Publicado: (2012)

Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells
por: Kandouz, Mustapha, et al.
Publicado: (2013)

What is pH regulation, and why do cancer cells need it?
por: Swietach, Pawel
Publicado: (2019)

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
por: Dovmark, T H, et al.
Publicado: (2017)

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication
por: Fumagalli, Amos, et al.
Publicado: (2020)

Divergent Cl(-) and H(+) pathways underlie transport coupling and gating in CLC exchangers and channels
por: Leisle, Lilia, et al.
Publicado: (2020)

hESC Expansion and Stemness Are Independent of Connexin Forty-Three-Mediated Intercellular Communication between hESCs and hASC Feeder Cells
por: Kim, Jin-Su, et al.
Publicado: (2013)

Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis
por: Lloyd, Shane A, et al.
Publicado: (2014)

Plasmalogens Regulate Retinal Connexin 43 Expression and Müller Glial Cells Gap Junction Intercellular Communication and Migration
por: Karadayi, Rémi, et al.
Publicado: (2022)

Betacellulin regulates gap junction intercellular communication by inducing the phosphorylation of connexin 43 in human granulosa-lutein cells
por: Li, Yuxi, et al.
Publicado: (2023)

Characterization of an Invertase with pH Tolerance and Truncation of Its N-Terminal to Shift Optimum Activity toward Neutral pH
por: Du, Liqin, et al.
Publicado: (2013)

Sequence homolog-based molecular engineering for shifting the enzymatic pH optimum
por: Ma, Fuqiang, et al.
Publicado: (2016)

Conformational changes in a pore-forming region underlie voltage-dependent “loop gating” of an unapposed connexin hemichannel
por: Tang, Qingxiu, et al.
Publicado: (2009)

Connexin 26 and Connexin 43 in Canine Mammary Carcinoma
por: Luu, Savannah, et al.
Publicado: (2019)

The acid test for pH-dependent gating in cloned H(V)1 channels
por: Islas, León D.
Publicado: (2018)

Function of Connexin-43 in Macrophages
por: Rodjakovic, Daniel, et al.
Publicado: (2021)

Enhanced Hydrogen Production at Optimum pH for the Recovery Cycle of β-FeOOH
por: Yoon, Younghwa, et al.
Publicado: (2022)

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E- cadherin
Publicado: (1991)

Dysregulation of lncRNA‐CCRR contributes to brain metastasis of breast cancer by intercellular coupling via regulating connexin 43 expression
por: Li, Deheng, et al.
Publicado: (2021)

ZIP1(+) fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn(2+) transfer
por: Ni, Chen, et al.
Publicado: (2022)

Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function
por: Molica, Filippo, et al.
Publicado: (2017)

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
por: Lee, Shen-Han, et al.
Publicado: (2018)

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems
por: Michl, Johanna, et al.
Publicado: (2019)

Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum
por: Malik, Erum, et al.
Publicado: (2021)

Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions
por: Rimkute, Lina, et al.
Publicado: (2018)

Internal translation of the connexin 43 transcript
por: Salat-Canela, Clàudia, et al.
Publicado: (2014)

The Role of Connexin 43 in Lung Disease
por: Swartzendruber, Julie A., et al.
Publicado: (2020)

Interactive mechanism between connexin43 and Cd-induced autophagic flux blockage and gap junctional intercellular communication dysfunction in rat hepatocytes
por: Duan, Yuntian, et al.
Publicado: (2023)

Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry
por: Zhong, Guoqiang, et al.
Publicado: (2017)

Histidine(168) is crucial for ΔpH-dependent gating of the human voltage-gated proton channel, hH(V)1
por: Cherny, Vladimir V., et al.
Publicado: (2018)

Phase Behavior of Aqueous Biphasic Systems with Choline Alkanoate Ionic Liquids and Phosphate Solutions: The Influence of pH
por: Berton, Paula, et al.
Publicado: (2021)

Hyperbranched polyethylenimine bearing cyclodextrin moieties showing temperature and pH controlled dye release
por: Böhm, Indra, et al.
Publicado: (2011)

A Voltage-Gated H(+) Channel Underlying pH Homeostasis in Calcifying Coccolithophores
por: Taylor, Alison R., et al.
Publicado: (2011)

Voltage and pH sensing by the voltage-gated proton channel, H(V)1
por: DeCoursey, Thomas E.
Publicado: (2018)

An Extracellular Tetrathionate Hydrolase from the Thermoacidophilic Archaeon Acidianus Ambivalens with an Activity Optimum at pH 1
por: Protze, Jonas, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jq3mp3eaqtq0jjpk35pe1d8to9