Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells

We recently reported that the Smac mimetic BV6 and glucocorticoids, e.g. Dexamethasone (Dexa), synergize to induce cell death in acute lymphoblastic leukemia (ALL) in vitro and in vivo. Here, we discover that this synergism involves Dexa-stimulated downregulation of cellular FLICE-like inhibitory pr...

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Detalles Bibliográficos
Autores principales: Kleinesudeik, Lara, Rohde, Katharina, Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893259/
https://www.ncbi.nlm.nih.gov/pubmed/29662664
http://dx.doi.org/10.18632/oncotarget.24782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893259/
https://www.ncbi.nlm.nih.gov/pubmed/29662664
http://dx.doi.org/10.18632/oncotarget.24782

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