A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein

Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZ) has been shown to be protective, but the features of the antibody response induced by this treatment remain unclear. To investigate this response at high resolution, we isolated IgM and IgG monoclonal antibodies from Tanzanian vo...

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Detalles Bibliográficos
Autores principales: Tan, Joshua, Sack, Brandon K, Oyen, David, Zenklusen, Isabelle, Piccoli, Luca, Barbieri, Sonia, Foglierini, Mathilde, Fregni, Chiara Silacci, Marcandalli, Jessica, Jongo, Said, Abdulla, Salim, Perez, Laurent, Corradin, Giampietro, Varani, Luca, Sallusto, Federica, Sim, B Kim Lee, Hoffman, Stephen L, Kappe, Stefan H I, Daubenberger, Claudia, Wilson, Ian A, Lanzavecchia, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893353/
https://www.ncbi.nlm.nih.gov/pubmed/29554084
http://dx.doi.org/10.1038/nm.4513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893353/
https://www.ncbi.nlm.nih.gov/pubmed/29554084
http://dx.doi.org/10.1038/nm.4513

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