DNA methylation loss in late-replicating domains is linked to mitotic cell division

DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-associated, late-replicating regions termed Partially Methylated Domains (PMDs). We profiled 39 diverse primary tumors and 8 matched adjacent tissues using Whole-Genome Bisulfite Sequencing (WGBS), and analyzed them al...

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Detalles Bibliográficos
Autores principales: Zhou, Wanding, Dinh, Huy Q., Ramjan, Zachary, Weisenberger, Daniel J., Nicolet, Charles M., Shen, Hui, Laird, Peter W., Berman, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893360/
https://www.ncbi.nlm.nih.gov/pubmed/29610480
http://dx.doi.org/10.1038/s41588-018-0073-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893360/
https://www.ncbi.nlm.nih.gov/pubmed/29610480
http://dx.doi.org/10.1038/s41588-018-0073-4

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