Low-dose tributyltin exposure induces an oxidative stress-triggered JNK-related pancreatic β-cell apoptosis and a reversible hypoinsulinemic hyperglycemia in mice

Tributyltin (TBT), an endocrine disrupting chemical, can be found in food (particular in fish and seafood) and drinking water by contamination. Here, we elucidated the effects and possible mechanisms of low-dose TBT on the growth and function of pancreatic β-cells and glucose metabolism in mice. Sub...

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Detalles Bibliográficos
Autores principales: Huang, Chun-Fa, Yang, Ching-Yao, Tsai, Jing-Ren, Wu, Cheng-Tien, Liu, Shing-Hwa, Lan, Kuo-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893562/
https://www.ncbi.nlm.nih.gov/pubmed/29636531
http://dx.doi.org/10.1038/s41598-018-24076-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893562/
https://www.ncbi.nlm.nih.gov/pubmed/29636531
http://dx.doi.org/10.1038/s41598-018-24076-w

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