Increased formate overflow is a hallmark of oxidative cancer

Formate overflow coupled to mitochondrial oxidative metabolism\ has been observed in cancer cell lines, but whether that takes place in the tumor microenvironment is not known. Here we report the observation of serine catabolism to formate in normal murine tissues, with a relative rate correlating w...

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Detalles Bibliográficos
Autores principales: Meiser, Johannes, Schuster, Anne, Pietzke, Matthias, Vande Voorde, Johan, Athineos, Dimitris, Oizel, Kristell, Burgos-Barragan, Guillermo, Wit, Niek, Dhayade, Sandeep, Morton, Jennifer P., Dornier, Emmanuel, Sumpton, David, Mackay, Gillian M., Blyth, Karen, Patel, Ketan J., Niclou, Simone P., Vazquez, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893600/
https://www.ncbi.nlm.nih.gov/pubmed/29636461
http://dx.doi.org/10.1038/s41467-018-03777-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893600/
https://www.ncbi.nlm.nih.gov/pubmed/29636461
http://dx.doi.org/10.1038/s41467-018-03777-w

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