Prediction of spacer-α6 complex: a novel insight into binding of ADAMTS13 with A2 domain of von Willebrand factor under forces

Force-regulated cleavage of A2 domain of von Willebrand factor (vWF) by ADAMTS13 is a key event in preventing thrombotic thrombocytopenic purpura (TTP). Recognition and cleavage depend on cooperative and modular contacts between several ADAMTS13 subdomains and discrete segments of vWF A2 domain. Spa...

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Detalles Bibliográficos
Autores principales: Fang, Xiang, Lin, Jiangguo, Fang, Ying, Wu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893608/
https://www.ncbi.nlm.nih.gov/pubmed/29636514
http://dx.doi.org/10.1038/s41598-018-24212-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893608/
https://www.ncbi.nlm.nih.gov/pubmed/29636514
http://dx.doi.org/10.1038/s41598-018-24212-6

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