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Prophylactic and Therapeutic Effects of Interleukin-2 (IL-2)/Anti-IL-2 Complexes in Systemic Lupus Erythematosus-Like Chronic Graft-Versus-Host Disease

Murine chronic graft-versus-host-disease (cGvHD) induced by injection of parental lymphocytes into F1 hybrids results in a disease similar to systemic lupus erythematosus. Here, we have used DBA/2 T cell injection into (C57BL/6 × DBA/2)F1 (BDF1) mice as a model system to test the prophylactic and th...

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Detalles Bibliográficos
Autores principales: Heiler, Stefan, Lötscher, Jonas, Kreuzaler, Matthias, Rolink, Johanna, Rolink, Antonius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893767/
https://www.ncbi.nlm.nih.gov/pubmed/29670626
http://dx.doi.org/10.3389/fimmu.2018.00656