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Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling

BACKGROUND: Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain swelling, vascular dysfunction, coma, and increas...

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Detalles Bibliográficos
Autores principales: Liu, Mingli, Solomon, Wesley, Cespedes, Juan Carlos, Wilson, Nana O., Ford, Byron, Stiles, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894207/
https://www.ncbi.nlm.nih.gov/pubmed/29636063
http://dx.doi.org/10.1186/s12974-018-1147-z