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Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease
The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both barrier formation and for the uptake and vectorial transport of nutrients. The establishment of cell polarity requi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894939/ https://www.ncbi.nlm.nih.gov/pubmed/29590640 http://dx.doi.org/10.1242/dmm.031088 |
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author | Schneeberger, Kerstin Roth, Sabrina Nieuwenhuis, Edward E. S. Middendorp, Sabine |
author_facet | Schneeberger, Kerstin Roth, Sabrina Nieuwenhuis, Edward E. S. Middendorp, Sabine |
author_sort | Schneeberger, Kerstin |
collection | PubMed |
description | The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both barrier formation and for the uptake and vectorial transport of nutrients. The establishment of cell polarity requires a specialized subcellular machinery to transport and recycle proteins to their appropriate location. In order to understand and treat polarity-associated diseases, it is necessary to understand epithelial cell-specific trafficking mechanisms. In this Review, we focus on cell polarity in the adult mammalian intestine. We discuss how intestinal epithelial polarity is established and maintained, and how disturbances in the trafficking machinery can lead to a polarity-associated disorder, microvillus inclusion disease (MVID). Furthermore, we discuss the recent developments in studying MVID, including the creation of genetically manipulated cell lines, mouse models and intestinal organoids, and their uses in basic and applied research. |
format | Online Article Text |
id | pubmed-5894939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58949392018-04-12 Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease Schneeberger, Kerstin Roth, Sabrina Nieuwenhuis, Edward E. S. Middendorp, Sabine Dis Model Mech Review The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both barrier formation and for the uptake and vectorial transport of nutrients. The establishment of cell polarity requires a specialized subcellular machinery to transport and recycle proteins to their appropriate location. In order to understand and treat polarity-associated diseases, it is necessary to understand epithelial cell-specific trafficking mechanisms. In this Review, we focus on cell polarity in the adult mammalian intestine. We discuss how intestinal epithelial polarity is established and maintained, and how disturbances in the trafficking machinery can lead to a polarity-associated disorder, microvillus inclusion disease (MVID). Furthermore, we discuss the recent developments in studying MVID, including the creation of genetically manipulated cell lines, mouse models and intestinal organoids, and their uses in basic and applied research. The Company of Biologists Ltd 2018-02-01 /pmc/articles/PMC5894939/ /pubmed/29590640 http://dx.doi.org/10.1242/dmm.031088 Text en © 2018. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Schneeberger, Kerstin Roth, Sabrina Nieuwenhuis, Edward E. S. Middendorp, Sabine Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease |
title | Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease |
title_full | Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease |
title_fullStr | Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease |
title_full_unstemmed | Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease |
title_short | Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease |
title_sort | intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894939/ https://www.ncbi.nlm.nih.gov/pubmed/29590640 http://dx.doi.org/10.1242/dmm.031088 |
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