Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegenerative diseases. Th...

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Detalles Bibliográficos
Autores principales: Sorrells, Shelly, Nik, Sara, Casey, Mattie, Cameron, Rosannah C., Truong, Harold, Toruno, Cristhian, Gulfo, Michelle, Lowe, Albert, Jette, Cicely, Stewart, Rodney A., Bowman, Teresa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894942/
https://www.ncbi.nlm.nih.gov/pubmed/29419415
http://dx.doi.org/10.1242/dmm.031583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894942/
https://www.ncbi.nlm.nih.gov/pubmed/29419415
http://dx.doi.org/10.1242/dmm.031583

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