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Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

Preeclampsia is one of the most serious complications of pregnancy. Currently there are no medical treatments. Given placental oxidative stress may be an early trigger in the pathogenesis of preeclampsia, therapies that enhance antioxidant pathways have been proposed as treatments. Melatonin is a di...

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Detalles Bibliográficos
Autores principales: Hannan, Natalie J., Binder, Natalie K., Beard, Sally, Nguyen, Tuong-Vi, Kaitu’u-Lino, Tu’uhevaha J., Tong, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894956/
https://www.ncbi.nlm.nih.gov/pubmed/29641523
http://dx.doi.org/10.1371/journal.pone.0187082