Simulations of CYP51A from Aspergillus fumigatus in a model bilayer provide insights into triazole drug resistance

Azole antifungal drugs target CYP51A in Aspergillus fumigatus by binding with the active site of the protein, blocking ergosterol biosynthesis. Resistance to azole antifungal drugs is now common, with a leucine to histidine amino acid substitution at position 98 the most frequent, predominantly conf...

Descripción completa

Detalles Bibliográficos
Autores principales: Nash, Anthony, Rhodes, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895076/
https://www.ncbi.nlm.nih.gov/pubmed/28992260
http://dx.doi.org/10.1093/mmy/myx056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895076/
https://www.ncbi.nlm.nih.gov/pubmed/28992260
http://dx.doi.org/10.1093/mmy/myx056

Ejemplares similares