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HEx: A heterologous expression platform for the discovery of fungal natural products

For decades, fungi have been a source of U.S. Food and Drug Administration–approved natural products such as penicillin, cyclosporine, and the statins. Recent breakthroughs in DNA sequencing suggest that millions of fungal species exist on Earth, with each genome encoding pathways capable of generat...

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Detalles Bibliográficos
Autores principales: Harvey, Colin J. B., Tang, Mancheng, Schlecht, Ulrich, Horecka, Joe, Fischer, Curt R., Lin, Hsiao-Ching, Li, Jian, Naughton, Brian, Cherry, James, Miranda, Molly, Li, Yong Fuga, Chu, Angela M., Hennessy, James R., Vandova, Gergana A., Inglis, Diane, Aiyar, Raeka S., Steinmetz, Lars M., Davis, Ronald W., Medema, Marnix H., Sattely, Elizabeth, Khosla, Chaitan, St. Onge, Robert P., Tang, Yi, Hillenmeyer, Maureen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895447/
https://www.ncbi.nlm.nih.gov/pubmed/29651464
http://dx.doi.org/10.1126/sciadv.aar5459