Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

Altered re-wiring of cell metabolism and transcriptional programs are both hallmarks of cancer that sustain rapid proliferation and metastasis(1). However mechanisms controlling the interplay between metabolic reprogramming and transcriptional regulation remain elusive. Here we show that metabolic e...

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Detalles Bibliográficos
Autores principales: Dasgupta, Subhamoy, Rajapakshe, Kimal, Zhu, Bokai, Nikolai, Bryan C., Yi, Ping, Putluri, Nagireddy, Choi, Jong Min, Jung, Sung Y., Coarfa, Cristian, Westbrook, Thomas F., Zhang, Xiang H.-F., Foulds, Charles E., Tsai, Sophia Y., Tsai, Ming-Jer, O’Malley, Bert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895503/
https://www.ncbi.nlm.nih.gov/pubmed/29615789
http://dx.doi.org/10.1038/s41586-018-0018-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895503/
https://www.ncbi.nlm.nih.gov/pubmed/29615789
http://dx.doi.org/10.1038/s41586-018-0018-1

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