Wild-type and mutated IDH1/2 enzymes and therapy responses

Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the development and/or progression of various types of cancer due to supraphysiological production of d-2-hydroxyglutarate. In various...

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Detalles Bibliográficos
Autores principales: Molenaar, Remco J., Maciejewski, Jaroslaw P., Wilmink, Johanna W., van Noorden, Cornelis J. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895605/
https://www.ncbi.nlm.nih.gov/pubmed/29367755
http://dx.doi.org/10.1038/s41388-017-0077-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895605/
https://www.ncbi.nlm.nih.gov/pubmed/29367755
http://dx.doi.org/10.1038/s41388-017-0077-z

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