PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma

Rhabdomyosarcoma is the most common soft-tissue sarcoma in childhood and histologically resembles developing skeletal muscle. Alveolar rhabdomyosarcoma (ARMS) is an aggressive subtype with a higher rate of metastasis and poorer prognosis. The majority of ARMS tumors (80%) harbor a PAX3-FOXO1 or less...

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Detalles Bibliográficos
Autores principales: Hanna, Jason A., Garcia, Matthew R., Lardennois, Alicia, Leavey, Patrick J., Maglic, Dino, Fagnan, Alexandre, Go, Jonathan C., Roach, Jordan, Wang, Yong-Dong, Finkelstein, David, Hatley, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895609/
https://www.ncbi.nlm.nih.gov/pubmed/29367756
http://dx.doi.org/10.1038/s41388-017-0081-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895609/
https://www.ncbi.nlm.nih.gov/pubmed/29367756
http://dx.doi.org/10.1038/s41388-017-0081-3

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