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Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate

The chaperone ClpB in bacteria is responsible for the reactivation of aggregated proteins in collaboration with the DnaK system. Association of these chaperones at the aggregate surface stimulates ATP hydrolysis, which mediates substrate remodeling. However, a question that remains unanswered is whe...

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Detalles Bibliográficos
Autores principales: Fernández-Higuero, Jose Angel, Aguado, Alejandra, Perales-Calvo, Judit, Moro, Fernando, Muga, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895705/
https://www.ncbi.nlm.nih.gov/pubmed/29643454
http://dx.doi.org/10.1038/s41598-018-24140-5