Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle

Self-assembling proteins are critical to biological systems and industrial technologies, but predicting how mutations affect self-assembly remains a significant challenge. Here, we report a technique, termed SyMAPS (Systematic Mutation and Assembled Particle Selection), that can be used to character...

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Detalles Bibliográficos
Autores principales: Hartman, Emily C., Jakobson, Christopher M., Favor, Andrew H., Lobba, Marco J., Álvarez-Benedicto, Ester, Francis, Matthew B., Tullman-Ercek, Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895741/
https://www.ncbi.nlm.nih.gov/pubmed/29643335
http://dx.doi.org/10.1038/s41467-018-03783-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895741/
https://www.ncbi.nlm.nih.gov/pubmed/29643335
http://dx.doi.org/10.1038/s41467-018-03783-y

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