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Allosteric regulation alters carrier domain translocation in pyruvate carboxylase

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. The reaction occurs in two separate catalytic domains, coupled by the long-range translocation of a biotinylated carrier domain (BCCP). Here, we use a series of hybrid PC enzymes to examine multiple BCCP...

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Detalles Bibliográficos
Autores principales: Liu, Yumeng, Budelier, Melissa M., Stine, Katelyn, St. Maurice, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895798/
https://www.ncbi.nlm.nih.gov/pubmed/29643369
http://dx.doi.org/10.1038/s41467-018-03814-8