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Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis

BACKGROUND: In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonical pathways. In the canonical pathway, the binding of canonical ligands such as...

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Detalles Bibliográficos
Autores principales: Ríos, Juvenal A., Godoy, Juan A., Inestrosa, Nibaldo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896060/
https://www.ncbi.nlm.nih.gov/pubmed/29642895
http://dx.doi.org/10.1186/s12964-018-0227-0