Gene-level differential analysis at transcript-level resolution

Compared to RNA-sequencing transcript differential analysis, gene-level differential expression analysis is more robust and experimentally actionable. However, the use of gene counts for statistical analysis can mask transcript-level dynamics. We demonstrate that ‘analysis first, aggregation second,...

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Detalles Bibliográficos
Autores principales: Yi, Lynn, Pimentel, Harold, Bray, Nicolas L., Pachter, Lior
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896116/
https://www.ncbi.nlm.nih.gov/pubmed/29650040
http://dx.doi.org/10.1186/s13059-018-1419-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896116/
https://www.ncbi.nlm.nih.gov/pubmed/29650040
http://dx.doi.org/10.1186/s13059-018-1419-z

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