Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity. However, we observed that rapid, extensive, drug-induced chan...

Descripción completa

Detalles Bibliográficos
Autores principales: Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896174/
https://www.ncbi.nlm.nih.gov/pubmed/29590629
http://dx.doi.org/10.1016/j.celrep.2018.03.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896174/
https://www.ncbi.nlm.nih.gov/pubmed/29590629
http://dx.doi.org/10.1016/j.celrep.2018.03.012

Ejemplares similares