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Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment

Aging is linked to functional deterioration and hematological diseases. The hematopoietic system is maintained by hematopoietic stem cells (HSCs), and dysfunction within the HSC compartment is thought to be a key mechanism underlying age-related hematopoietic perturbations. Using single-cell transpl...

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Detalles Bibliográficos
Autores principales: Yamamoto, Ryo, Wilkinson, Adam C., Ooehara, Jun, Lan, Xun, Lai, Chen-Yi, Nakauchi, Yusuke, Pritchard, Jonathan K., Nakauchi, Hiromitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896201/
https://www.ncbi.nlm.nih.gov/pubmed/29625072
http://dx.doi.org/10.1016/j.stem.2018.03.013