Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection

The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested in a screeening cascade for MMP inhibition. W...

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Detalles Bibliográficos
Autores principales: Bencsik, Péter, Kupai, Krisztina, Görbe, Anikó, Kenyeres, Éva, Varga, Zoltán V., Pálóczi, János, Gáspár, Renáta, Kovács, László, Weber, Lutz, Takács, Ferenc, Hajdú, István, Fabó, Gabriella, Cseh, Sándor, Barna, László, Csont, Tamás, Csonka, Csaba, Dormán, György, Ferdinandy, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896266/
https://www.ncbi.nlm.nih.gov/pubmed/29674965
http://dx.doi.org/10.3389/fphar.2018.00296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896266/
https://www.ncbi.nlm.nih.gov/pubmed/29674965
http://dx.doi.org/10.3389/fphar.2018.00296

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