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Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones
Misfolding of proteins is the basis of several proteinopathies. Chemical and pharmacological chaperones are small molecules capable of inducing the correct conformation of proteins, thus being of interest for human therapeutics. The most recent developments in medicinal chemistry and in the drug dev...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896381/ https://www.ncbi.nlm.nih.gov/pubmed/29719681 http://dx.doi.org/10.1039/c7sc04712f |