Formyl Met-Leu-Phe-Stimulated FPR1 Phosphorylation in Plate-Adherent Human Neutrophils: Enhanced Proteolysis but Lack of Inhibition by Platelet-Activating Factor

N-formyl-Met-Leu-Phe (fMLF) is a model PAMP/DAMP driving human PMN to sites of injury/infection utilizing the GPCR, FPR1. We examined a microtiter plate format for measurement of FPR1 phosphorylation in adherent PMN at high densities and found that a new phosphosensitive FPR1 fragment, 25K-FPR1, acc...

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Detalles Bibliográficos
Autores principales: Jesaitis, Algirdas J., Gripentrog, Jeannie, Voyich, Jovanka M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896419/
https://www.ncbi.nlm.nih.gov/pubmed/29785402
http://dx.doi.org/10.1155/2018/3178970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896419/
https://www.ncbi.nlm.nih.gov/pubmed/29785402
http://dx.doi.org/10.1155/2018/3178970

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