Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells

PURPOSE: Lysophosphatidic acid (LPA), a bioactive lipid, has been shown to increase resistance to aqueous humor outflow (AH) through the trabecular meshwork (TM). The molecular basis for this response of the TM to LPA, however, is not completely understood. In this study, we explored the possible in...

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Detalles Bibliográficos
Autores principales: Ho, Leona T. Y., Skiba, Nikolai, Ullmer, Christoph, Rao, Ponugoti Vasantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896423/
https://www.ncbi.nlm.nih.gov/pubmed/29677358
http://dx.doi.org/10.1167/iovs.17-23702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896423/
https://www.ncbi.nlm.nih.gov/pubmed/29677358
http://dx.doi.org/10.1167/iovs.17-23702

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