Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity

OBJECTIVE: This study reports a preclinical evaluation of an alginate/chitosan nanoparticle formulation containing NovaBupi®, a racemic bupivacaine (BVC) containing 25% dextrobupivacaine and 75% levobupivacaine. METHODS: New Zealand White rabbits (n=6) received intraoral or intrathecal injections of...

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Detalles Bibliográficos
Autores principales: Cereda, Cíntia Maria Saia, Mecatti, Daniel Sebbe, Papini, Juliana Zampoli Boava, Bueno, Diego Valério, Franz-Montan, Michelle, Rocha, Thalita, Pedrazzoli Júnior, José, de Paula, Eneida, de Araújo, Daniele Ribeiro, Grillo, Renato, Fraceto, Leonardo Fernandes, Calafatti, Silvana Aparecida, Tofoli, Giovana Radomille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896646/
https://www.ncbi.nlm.nih.gov/pubmed/29670395
http://dx.doi.org/10.2147/JPR.S158695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896646/
https://www.ncbi.nlm.nih.gov/pubmed/29670395
http://dx.doi.org/10.2147/JPR.S158695

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