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Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies

[Image: see text] Membrane proteins perform a host of vital cellular functions. Deciphering the molecular mechanisms whereby they fulfill these functions requires detailed biophysical and structural investigations. Detergents have proven pivotal to extract the protein from its native surroundings. Y...

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Detalles Bibliográficos
Autores principales: Chipot, Christophe, Dehez, François, Schnell, Jason R., Zitzmann, Nicole, Pebay-Peyroula, Eva, Catoire, Laurent J., Miroux, Bruno, Kunji, Edmund R. S., Veglia, Gianluigi, Cross, Timothy A., Schanda, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896743/
https://www.ncbi.nlm.nih.gov/pubmed/29488756
http://dx.doi.org/10.1021/acs.chemrev.7b00570