Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

The sodium-independent cystine-glutamate antiporter plays an important role in extracellular cystine uptake. It comprises the transmembrane protein, xCT and its chaperone, CD98. Because glutathione is only weakly cell membrane permeable, cellular uptake of its precursor, cystine, is known to be a ke...

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Detalles Bibliográficos
Autores principales: Nagane, Masaki, Kanai, Eiichi, Shibata, Yuki, Shimizu, Takuto, Yoshioka, Chie, Maruo, Takuya, Yamashita, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896924/
https://www.ncbi.nlm.nih.gov/pubmed/29649284
http://dx.doi.org/10.1371/journal.pone.0195151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896924/
https://www.ncbi.nlm.nih.gov/pubmed/29649284
http://dx.doi.org/10.1371/journal.pone.0195151

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