Cargando…

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

The sodium-independent cystine-glutamate antiporter plays an important role in extracellular cystine uptake. It comprises the transmembrane protein, xCT and its chaperone, CD98. Because glutathione is only weakly cell membrane permeable, cellular uptake of its precursor, cystine, is known to be a ke...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nagane, Masaki, Kanai, Eiichi, Shibata, Yuki, Shimizu, Takuto, Yoshioka, Chie, Maruo, Takuya, Yamashita, Tadashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896924/ https://www.ncbi.nlm.nih.gov/pubmed/29649284 http://dx.doi.org/10.1371/journal.pone.0195151

Ejemplares similares

Increased expression of cystine/glutamate antiporter in multiple sclerosis
por: Pampliega, Olatz, et al.
Publicado: (2011)

Change of cystine/glutamate antiporter expression in ethanol-dependent rats
por: Peana, Alessandra T., et al.
Publicado: (2014)

Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues
por: Martis, Renita M., et al.
Publicado: (2020)

The System xc- Cystine/Glutamate Antiporter: An Exciting Target for Antiepileptogenic Therapy?
por: Gallagher, Martin
Publicado: (2020)

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter
por: Bentea, Eduard, et al.
Publicado: (2020)

Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment
por: Hung, Chung-Chieh, et al.
Publicado: (2021)

Molecular basis for redox control by the human cystine/glutamate antiporter system xc(−)
por: Parker, Joanne L., et al.
Publicado: (2021)

Early Onset of Age-Related Cataracts in Cystine/Glutamate Antiporter Knockout Mice
por: Martis, Renita Maria, et al.
Publicado: (2021)

High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells
por: Thomas, Ajit G., et al.
Publicado: (2015)

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
por: Shin, Chun-Shik, et al.
Publicado: (2017)

Cystine/glutamate antiporter System x(c)(-) deficiency impairs insulin secretion in mice
por: de Baat, Axel, et al.
Publicado: (2023)

Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
por: Fournier, M., et al.
Publicado: (2017)

Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury
por: Meyer, Anne R., et al.
Publicado: (2019)

The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer
por: Jyotsana, Nidhi, et al.
Publicado: (2022)

Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission
por: Fukuyama, Kouji, et al.
Publicado: (2018)

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
por: Arensman, Michael D., et al.
Publicado: (2019)

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis
por: Ashraf, Azhaar, et al.
Publicado: (2020)

Cystine/Glutamate antiporter system x(c)(-) deficiency impairs macrophage glutathione metabolism and cytokine production
por: de Baat, Axel, et al.
Publicado: (2023)

The cystine/glutamate antiporter system x(c)(−) drives breast tumor cell glutamate release and cancer-induced bone pain
por: Slosky, Lauren M., et al.
Publicado: (2016)

Sulfasalazine, a potent cystine-glutamate transporter inhibitor, enhances osteogenic differentiation of canine adipose-derived stem cells
por: ITOH, Harumichi, et al.
Publicado: (2023)

The x(c)(−) cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance
por: Lo, M, et al.
Publicado: (2008)

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
por: Vallerga, Costanza L., et al.
Publicado: (2020)

Cystine–glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice
por: Sprimont, Lindsay, et al.
Publicado: (2021)

Immunotherapy against the Cystine/Glutamate Antiporter xCT Improves the Efficacy of APR-246 in Preclinical Breast Cancer Models
por: Barutello, Giuseppina, et al.
Publicado: (2022)

[(18)F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis
por: Hoehne, Aileen, et al.
Publicado: (2018)

The Cystine/Glutamate Antiporter, System x(c)(–), Contributes to Cortical Infarction After Moderate but Not Severe Focal Cerebral Ischemia in Mice
por: He, Yan, et al.
Publicado: (2022)

Structural investigation of human cystine/glutamate antiporter system x(c) (−) (Sx(c) (−)) using homology modeling and molecular dynamics
por: Hang, Tran Dieu, et al.
Publicado: (2022)

Yokukansan, a Kampo Medicine, Protects PC12 Cells from Glutamate-Induced Death by Augmenting Gene Expression of Cystine/Glutamate Antiporter System Xc(−)
por: Kanno, Hitomi, et al.
Publicado: (2014)

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
por: Lim, Jonathan K. M., et al.
Publicado: (2019)

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
por: Hasegawa, Masanori, et al.
Publicado: (2016)

Diagnosing Alzheimer’s Disease Specifically and Sensitively With pLG72 and Cystine/Glutamate Antiporter SLC7A11 AS Blood Biomarkers
por: Lane, Hsien-Yuan, et al.
Publicado: (2022)

Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models
por: Ruiu, Roberto, et al.
Publicado: (2023)

Repurposing Sulfasalazine as a Radiosensitizer in Hypoxic Human Colorectal Cancer
por: Kerkhove, Lisa, et al.
Publicado: (2023)

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs)
por: Koch, Katharina, et al.
Publicado: (2021)

Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress
por: Akiyama, Masahiro, et al.
Publicado: (2022)

Symport and antiport mechanisms of human glutamate transporters
por: Qiu, Biao, et al.
Publicado: (2023)

Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent manner
por: Li, Qing, et al.
Publicado: (2021)

Rotavirus-induced lncRNA SLC7A11-AS1 promotes ferroptosis by targeting cystine/glutamate antiporter xCT (SLC7A11) to facilitate virus infection
por: Banerjee, Shreya, et al.
Publicado: (2023)

Tonic extracellular glutamate and ischaemia: glutamate antiporter system x(c) (−) regulates anoxic depolarization in hippocampus
por: Heit, Bradley S., et al.
Publicado: (2022)

Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice
por: Taguchi, Kumiko, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ao1gufuclnevqip6repkp96tje