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P38 activation induces the dissociation of tristetraprolin from Argonaute 2 to increase ARE-mRNA stabilization
Tristetraprolin (TTP) destabilizes AU-rich element (ARE)-containing mRNA by directly binding with their 3′UTR. P38 stimulation substantially increases ARE-mRNA stability, at least through repressing TTP. However, the mechanism by which P38 keeps TTP inactive has not been fully understood. TTP and AR...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896936/ https://www.ncbi.nlm.nih.gov/pubmed/29444957 http://dx.doi.org/10.1091/mbc.E17-02-0105 |