TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast

The events underlying senescence induced by critical telomere shortening are not fully understood. Here we provide evidence that TERRA, a non-coding RNA transcribed from subtelomeres, contributes to senescence in yeast lacking telomerase (tlc1Δ). Levels of TERRA expressed from multiple telomere ends...

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Detalles Bibliográficos
Autores principales: Wanat, Jennifer J., Logsdon, Glennis A., Driskill, Jordan H., Deng, Zhong, Lieberman, Paul M., Johnson, F. Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896980/
https://www.ncbi.nlm.nih.gov/pubmed/29649255
http://dx.doi.org/10.1371/journal.pone.0195698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896980/
https://www.ncbi.nlm.nih.gov/pubmed/29649255
http://dx.doi.org/10.1371/journal.pone.0195698

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