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Finding the molecular scaffold of nuclear receptor inhibitors through high-throughput screening based on proteochemometric modelling
Nuclear receptors (NR) are a class of proteins that are responsible for sensing steroid and thyroid hormones and certain other molecules. In that case, NR have the ability to regulate the expression of specific genes and associated with various diseases, which make it essential drug targets. Approac...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897275/ https://www.ncbi.nlm.nih.gov/pubmed/29651663 http://dx.doi.org/10.1186/s13321-018-0275-x |