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Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates

In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty. To understand the neuroendocrine mechanism of puberty, we investigated...

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Autores principales: Terasawa, Ei, Garcia, James P., Seminara, Stephanie B., Keen, Kim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897421/
https://www.ncbi.nlm.nih.gov/pubmed/29681889
http://dx.doi.org/10.3389/fendo.2018.00148
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author Terasawa, Ei
Garcia, James P.
Seminara, Stephanie B.
Keen, Kim L.
author_facet Terasawa, Ei
Garcia, James P.
Seminara, Stephanie B.
Keen, Kim L.
author_sort Terasawa, Ei
collection PubMed
description In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty. To understand the neuroendocrine mechanism of puberty, we investigated the contribution of kisspeptin and NKB signaling to the pubertal increase in GnRH release using rhesus monkeys as a model. Direct measurements of GnRH and kisspeptin in the median eminence of the hypothalamus with infusion of agonists and antagonists for kisspeptin and NKB reveal that kisspeptin and NKB signaling stimulate GnRH release independently or collaboratively by forming kisspeptin and NKB neuronal networks depending on the developmental age. For example, while in prepubertal females, kisspeptin and NKB signaling independently stimulate GnRH release, in pubertal females, the formation of a collaborative kisspeptin and NKB network further accelerates the pubertal increase in GnRH release. It is speculated that the collaborative mechanism between kisspeptin and NKB signaling to GnRH neurons is necessary for the complex reproductive function in females.
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spelling pubmed-58974212018-04-20 Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates Terasawa, Ei Garcia, James P. Seminara, Stephanie B. Keen, Kim L. Front Endocrinol (Lausanne) Endocrinology In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty. To understand the neuroendocrine mechanism of puberty, we investigated the contribution of kisspeptin and NKB signaling to the pubertal increase in GnRH release using rhesus monkeys as a model. Direct measurements of GnRH and kisspeptin in the median eminence of the hypothalamus with infusion of agonists and antagonists for kisspeptin and NKB reveal that kisspeptin and NKB signaling stimulate GnRH release independently or collaboratively by forming kisspeptin and NKB neuronal networks depending on the developmental age. For example, while in prepubertal females, kisspeptin and NKB signaling independently stimulate GnRH release, in pubertal females, the formation of a collaborative kisspeptin and NKB network further accelerates the pubertal increase in GnRH release. It is speculated that the collaborative mechanism between kisspeptin and NKB signaling to GnRH neurons is necessary for the complex reproductive function in females. Frontiers Media S.A. 2018-04-06 /pmc/articles/PMC5897421/ /pubmed/29681889 http://dx.doi.org/10.3389/fendo.2018.00148 Text en Copyright © 2018 Terasawa, Garcia, Seminara and Keen. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Terasawa, Ei
Garcia, James P.
Seminara, Stephanie B.
Keen, Kim L.
Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates
title Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates
title_full Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates
title_fullStr Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates
title_full_unstemmed Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates
title_short Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates
title_sort role of kisspeptin and neurokinin b in puberty in female non-human primates
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897421/
https://www.ncbi.nlm.nih.gov/pubmed/29681889
http://dx.doi.org/10.3389/fendo.2018.00148
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