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Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia
Inducible DNA recombination of floxed alleles in vivo by liver metabolites of tamoxifen (TAM) is an important tool to study gene functions. Here, we describe protocols for optimal DNA recombination in astrocytes, based on the GLAST-Cre(ERT2)/loxP system. In addition, we demonstrate that quantificati...
Autores principales: | Jahn, Hannah M., Kasakow, Carmen V., Helfer, Andreas, Michely, Julian, Verkhratsky, Alexei, Maurer, Hans H., Scheller, Anja, Kirchhoff, Frank |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897555/ https://www.ncbi.nlm.nih.gov/pubmed/29651133 http://dx.doi.org/10.1038/s41598-018-24085-9 |
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