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Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging

Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age. Here, we develop a comprehensive metric for physiological age in Drosophila,...

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Detalles Bibliográficos
Autores principales: Spurrier, Joshua, Shukla, Arvind Kumar, McLinden, Kristina, Johnson, Kory, Giniger, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897722/
https://www.ncbi.nlm.nih.gov/pubmed/29469033
http://dx.doi.org/10.1242/dmm.031161