Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix

Aurora‐A regulates the recruitment of TACC3 to the mitotic spindle through a phospho‐dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these interactions, mediated by three motifs in a disordered region of TACC3. A hydrophobic docking motif binds to a p...

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Detalles Bibliográficos
Autores principales: Burgess, Selena G, Mukherjee, Manjeet, Sabir, Sarah, Joseph, Nimesh, Gutiérrez‐Caballero, Cristina, Richards, Mark W, Huguenin‐Dezot, Nicolas, Chin, Jason W, Kennedy, Eileen J, Pfuhl, Mark, Royle, Stephen J, Gergely, Fanni, Bayliss, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897774/
https://www.ncbi.nlm.nih.gov/pubmed/29510984
http://dx.doi.org/10.15252/embj.201797902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897774/
https://www.ncbi.nlm.nih.gov/pubmed/29510984
http://dx.doi.org/10.15252/embj.201797902

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